Salamanca has been linked to the history for a series of events and personalities thatcame to mark the evolution of Western society
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- The creation of the first castilian grammar in 1492 by Antonio de Nebrija, the famous Grammatica. It was the first research of the rules of an european language besides the Latin, this fact marked the beginning of the Spanish Gold Century.
- Nebrija was also the first person in the Western world to claim copyright.
- Preparations of Columbus for his first trip to the Discovery of America. The Faculty of the University of Salamanca was reached in Council to discuss his project. Over the years, Colon won the support of the Dominicans, staying at the Convent of San Esteban. The Salamanca astronomer Abraham Zacut was his great scientific support for the trip.
- The first woman Universitaire of world: Beatriz Galindo, «la Latina».
- The first female professor of university in the world, Lucia de Medrano, during the course1508-1509.
- The study years of Hernan Cortes before parting to America and conquer the Aztec empire.
- The rights of indigenous New World by the School of Salamanca, with Francisco de Vitoria to the head, reformulated the concept of natural law, renewed theology laid the foundations of modern international law, the right international and modern economics and participated actively in the Council of Trent.
- In this council, the mathematicians from the Salamanca University proposed to the Pope Gregory XIII, the calendar became known as the Gregorian calendar and is now used around the world.
- The fact that the first librarian with a salary of history was in the old library of the University of Salamanca.
- The partial translation of the Bible into Spanish, made by Fray Luis de León.
- The oldest printed chess book preserved, Repeticion de Amores y Arte de Ajedrez, by Luis Ramires de Lucena, Published on 1496 in Salamanca.
- The stay of Miguel de Cervantes Saavedra, who possibly was a student of the university, materialized in his books: The Cave of Salamanca, in Don Quixote in which he makes references to the character of Salamanca bachelor Samson Carrasco, The the aunt feigned Glass graduated with the quote:
“Salamanca que enhechiza la voluntad de volver a ella a todos los que de la apacibilidad de su vivienda han gustado”.